In the cyber-physical continuum, efficient interplay of sensors, actuators, network and computing is becoming increasingly critical.  As complexity of such systems grows, humans need to be able to rely on autonomous intelligent features more and more, and not only expect maximum performance given limited resources, but also adherence to trustworthy principles such as safety, explainability, security and privacy. In this talk, we will discuss how artificial intelligence can be used to optimize performance of cyber-physical systems while guaranteeing their mission-critical properties.